1. "I could promise to hold you and to cherish you. I could promise to be in sickness and in health. I could say, 'till death do us part.' But I won't. Those vows are for optimistic couples, the ones full of hope. And I do not stand here, on my wedding day, optimistic or full of hope. I am not optimistic; I am not hopeful. I am sure; I am steady. And I know that I am a heart man. So of this I am sure: you are my partner, my lover, my very best friend, my heart. My heart beats for you. And on this day, the day of our wedding, I promise you this: I promise you to lay my heart in the palm of your hands; I promise you me." -Preston Burke

2."I love you. I've always been in love with you. We're gonna have the best life, you and me. We're gonna be so happy. We're supposed to end up together. We're meant to be. I love you." -Mark Sloan

3. "You. You're everything. I love you, and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it." -Derek Shepard

4. "I'm with you. I'm with you because I want to be — I'm with you because I love you.” -Owen Hunt5. "[We vow] to love each other, even when we hate each other. No running, ever. Nobody walks out, no matter what happens. We'll take care of each other even when we're old and smelly and senile. This is forever." -Meredith Grey and Derek Shepard

6. "The only time I don't feel like a ghost is when you look at me, because when you look at me, you see me. You see me. This is me." -Owen Hunt

7. "I love you. I always have. I love everything about you. Even the things I don't like, I love. And I want you with me. I love you." -Jackson Avery

8. "Today's the day my life begins. All my life I've been just me, just a smart-mouthed kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you, to our future, to all the possibilities that our marriage has to offer. Together, no matter what happens, I'll be ready for anything, for everything . . . to take on life, to take on love, to take on possibility and responsibility. Today, our life together begins, and I, for one, can't wait." -Alex Karev9. "I will probably hurt you again and you'll hurt me. And I'll come right back to you again when you do. I accept the risk. Because you're worth it. Because you matter to me. Because I love you. And I'm not going anywhere." -Meredith Grey

10. "I can be a better man. I can be a better man for you. I hope, you know, if you'll let me. I can be a better man with you." -Owen Hunt

11. "You were like coming up for fresh air. It's like I was drowning and you saved me. That's all I know." -Derek Shepard

12. "I do love you. Don't you see? Don't you understand? You're the love of my life. I can't leave you." -Derek Shepard

13. "I promised I wouldn't run, I promised I would love you, even when I hate you." -Derek Shepard

14. "I love you, in a really really big, pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window, unfortunate way that makes me hate you, love you. So pick me. Choose me. Love me." -Meredith Grey15. "My world is a better place with you in it." -Richard Webber

16. "If you love someone, you tell them. Even if you’re scared that it’s not the right thing. Even if you’re scared that it’ll cause problems. Even if you’re scared that it will burn your life to the ground, you say it, and you say it loud and you go from there." -Mark Sloan17. "I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime." -Derek Shepard

18. "You didn’t love her. You just didn’t want to be alone. Or maybe, maybe she was good for your ego. Or maybe she made you feel better about your miserable life, but you didn’t love her, because you don’t destroy the person that you love." -Callie Torres19. "I believe that we could be extraordinary together rather than ordinary apart." -Meredith Grey

20. “Every kiss before the right kiss doesn’t count anyway. I’ve kissed a lot of women. The first time I kissed my wife, well, I mean she wasn’t my wife then; she was just this girl in a bar. And when we kissed, it was like – I got to tell you – it was like I never kissed any other woman before. It was like the first kiss, the right kiss.” -Derek Shepherd