It's been a long time since this medial drama sneaked its way into our hearts and, let's face it, our hearts (and tear ducts) have never been the same. We've all sat up late at night watching this heart-wrenching show with multiple empty tissue boxes scattered around us. Let's take a little stroll down Seattle Grace Mercy West memorial lane. Grab the tissues, this is gonna be emotional.

1. That time Addison shows up and ruins Meredith and Derek's bliss.

2. When Meredith confronted her father about walking out on her as a child.

3. Then when Denny died only an hour after he proposed to Izzie.

4. And of course, when Meredith confesses her love for Derek.

5. The homemade bomb on the day Meredith knew she should have stayed home.

6. When George's father died.

7. When Burke left Christiana at the alter.

8. Remember when Meredith drowned?

9. When Derek had a mental breakdown with Mer in the woods.

10. And when Owen had really bad PTSD.

11. And then he distanced himself from Christiana because he didn't want to hurt her.

12. Oh yeah.... Derek got shot.

13. AND Alex got shot.

14. When the gunman held a gun to Christiana's head while she was working on Derek.

15. There was the time Arizona crashed her car.

16. Then Teddy's man, Henry died.

17. Oh and the plane crash where Lexi died.

18. And Mark.

19. When Adele died during Bailey's wedding but Weber didn't want to upset her so him and Meredith just cried in the corner.

20. Remember Jackson's heroic efforts that saved a little girl from a fire seconds before it exploded?

21. AND then Arizona cheated on Callie.