Alex Karev has been on the show, "Grey's Anatomy," since the very beginning. This is a show that has seen a lot of tragedy from Shonda Rhimes, the head writer and one of the producers of "Grey's."

She has killed off some beloved characters such as Derek Shepherd, George O'Malley, Mark Sloan, and Lexie Grey. In addition, viewers have endured countless horrible events such as Derek being shot, the plane crash, and Meredith Grey almost drowning just to name a few.

Meredith Grey has had such a hard life from a very young age when her mother tried to kill herself right in front of her. Then Meredith did grow up to become an intern and then a surgeon at Seattle Grace hospital, later named Grey-Sloan Memorial hospital.

Through the many hardships of her life including her husband dying, stealing her own child, losing her mother, her best friend moving to Switzerland, getting sued for insurance fraud, and so many other events Alex Karev was there for her.

Yes, at first Alex Karev was very egotistical and arrogant, but his character development throughout the series is amazing.

Next up, Jo Wilson. Jo suffered from being abandoned from a young age, homelessness, depression and so much more. Her life changed when she met Alex Karev and they fell in love and got married.

Who knew Izzie Stevens would have the audacity to come back into Alex's life and say they had kids?! And so Alex left the love of his life, Jo Wilson, to go live with Izzie Stevens and their two kids together.

Let me just say, Jo Wilson deserved better. Alex left Jo, Meredith, and his mentors and bosses, Miranda Bailey and Richard Webber, by writing each a letter saying he was leaving.

Who leaves their entire life behind with only writing letters to the people you loved and loved you the most?

They ALL deserved better.