Your first semester in college is a huge learning experience. Since I've just completed my first semester at Villanova, now seems a good time to shed some light on the challenges I faced, what I would have done differently, and how I still managed to have a successful first semester.
For people stepping out of their comfort zones and heading off to universities far from home or where none of their friends are going, the early days of orientation and college life will undoubtedly be challenging. No matter how welcoming the student body, it will be hard to not feel alone and friendless. Give it time, and don't force anything. It took me almost a month to fully adjust to college life and to cement friendships and friend groups.
As anyone would say, getting involved in campus groups and activities is an easy way to make friends that share your interests. Don't panic and think you hate your school just because you feel uncomfortable for the first couple of weeks. Things get better in time.
In addition, at any university, and particularly more competitive and academically rigorous schools, you need to prepare yourself for a level of academic commitment foreign to most high school students. Professors will expect a lot and it will be essential that you have an in-depth and thorough understanding of course material.
If I could change anything about my first semester, I would dedicate more time to studying for my first couple of exams. I was not at all prepared for how in-depth and challenging the exams would be. In college, your final grades will be majorly composed of test grades. Taking hits on your first couple of exams will set you up for an even more challenging first semester. Don't be afraid to seek extra help from your professors if you need it, they will be more than willing to help.
I know none of what I have written is particularly revolutionary, but getting involved, studying hard, and seeking help when needed is the best advice I can give as someone who has just finished my first semester.