One drug may be safe while another is dangerous due to genetic differences. It is possible for there to be very serious adverse effects. It is possible that another person will not respond favorably to the same dose.
Pharmacogenomics vs. genetics
A sort of genetic testing known as "standard genetic testing" involves the search for particular genes. A test can identify the BRCA1 and BRCA2 genes, which are linked to breast and ovarian cancer, respectively. It's possible that using genetic testing as a norm might stimulate risk-reduction efforts. Examples:
â—ŹIncreased number of cancer screenings
â—ŹModifying lifestyle
â—ŹProphylactic
Genetic testing is an integral part of pharmacogenomics. It detects gene variants. These differences can either make drugs more effective, or less if the doctor uses the findings of the test to select the most effective drug and the appropriate dosage.
Pharmacogenomics evolves. Gene variants that affect how well drugs work have recently come to the attention of researchers. There is a chance that personalized medicine will lead to an increase in gene testing.
Why do different people have various responses to the medications they take?
For stimulant medications to be successful, many cancer treatments must first be "activated." This entails the process of activation. The body's chemistry is sped up thanks to the presence of enzymes. This is what gives a drug its therapeutic effect. There is a genetic component to enzymes. The rate at which drugs begin to work might be affected by various factors. Some species metabolize medications slowly. It's possible that the standard dosages won't work.
There is a possibility that slower enzymes will impact certain persons. As a result, elevated drug levels can continue in their systems. They risk experiencing additional negative effects brought on by the medication. Several other factors can influence a patient's pharmacological response in addition to pharmacogenomics, including the following:
â—ŹAge/gender
â—ŹToxic waste cancer
â—ŹSmoking and drinking are lifestyle behaviors
â—ŹAilments
â—ŹOther medications
Advantages of pharmacogenomics
â—ŹPatient safety may get better. Drug interactions are responsible for a massive number of hospitalizations every year. Patients who are at risk can be identified by pharmacogenomics.
â—ŹThis may increase both productivity and the reduction of costs. The selection of medications and dosages can be sped up with the help of pharmacogenomics.
Challenges posed by pharmacogenomics
â—ŹIt is a costly endeavor, particularly in the absence of insurance.
â—ŹAccess to the test may be restricted in certain regions.
â—ŹPrivacy issues continue to be raised despite the existence of laws that prohibit discrimination. It is against the law to be genetically prejudiced.
Clinical pharmacogenomics
In the treatment of cancer, pharmacogenomic testing may include the following:
CRC- Irinotecan, a drug used in chemotherapy (Camptosar) It is an approach that is frequently taken in the treatment of colon cancer. Specific mutations cause UGT1A1 deficiency in the human genome. Irinotecan is degraded as a result. The metabolism is beneficial to the processing of drugs. Irinotecan concentrations rise in response to a decrease in UGT1A1 activity. The repercussions of this behavior can be extremely dangerous. The higher the dose, the greater the potential danger.
Lymphocytosis (ALL)-Pharmacogenomic screening is performed on EVERY child. There are variants of the thiopurine methyltransferase gene in 10% of the general population (TPMT). TPMT is responsible for the metabolism of EVERY chemotherapeutic drug. Chemotherapy doses can be reduced when TPMT levels are low. This reduces the severity of the harmful repercussions.